Phospholipase

Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipases are defined by the enzymatic reaction they catalyze. The classes are phospholipase A, which has members A1 and A2; phospholipase B, which can carry out the reactions of both A1 and A2; phospholipase C; and phospholipase D.

Phospholipase A₂ (PLA₂) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP₂) to inositol 1,4,5-trisphosphate (IP₃) and diacylglycerol (DAG). DAG and IP₃ each control diverse cellular processes and are also substrates for synthesis of other important signaling molecules. PLC is thus central to many important interlocking regulatory networks. Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.

Phospholipase 相关产品（62）

货号	产品名	Cas	产品描述
PL09750	3-Nitrocoumarin	28448-04-6	3-Nitrocoumarin (3-NC) 是一个有效的、磷脂酶 C-γ (PLC-γ) 的选择性抑制剂。
PC12706	7-hydroxycoumarinyl Arachidonate	161180-11-6	cPLA2的底物，7-hydroxycoumarinyl-arachidonate (7-HCA), a fluorogenic substrate for monoacylglycerol lipase (MAGL), can be used with MAGL as a novel fluorescence-based assay to screen small molecule inhibitors of MAGL.
PC12644	AACOCF3	149301-79-1	cPLA2/大麻素水解/FAAH抑制剂，AACOCF3是一种强效的和选择性的胞液型磷脂酶A2抑制剂,IC50值为15 μM [1].
PL09751	Alminoprofen	39718-89-3	Alminoprofen 是苯丙酸类非甾体抗炎药 (NSAID)。Alminoprofen 同时具有抑制分泌磷脂酶A2 (sPLA2) 活性和抗环氧化酶 (COX-2) 的活性。
PC12725	Arachidonic Acid Leelamide(solution)		磷脂酶A2抑制剂，Arachidonic acid leelamide is a phospholipase A2 inhibitor.
PC12775	Bromoenol lactone	88070-98-8	心肌细胞溶质钙依赖性磷脂酶A2（iPLA2）的抑制剂，Bromoenol lactone ((6E)-Bromoenol lactone) 是一种不可逆的选择性的和有效的钙依赖性磷脂酶 A2 (iPLA2β) 抑制剂，其 IC50 值约为 7 μM，可抑制抗原刺激的肥大细胞胞吐作用，而不会阻止 Ca2+ 的大量涌入。
PC54188	CAY10502	888320-29-4	CAY10502 是一种有效的钙依赖性胞质磷脂酶 A2 α (cPLA2α) 抑制剂，对分离的酶具有 IC50 为 4.3 nM。CAY10502 可用于视网膜病变和炎症性疾病的研究。
PC54649	CAY10590	1101136-50-8	CAY10590 (GK115) 是一种分泌型磷脂酶 A2 (sPLA2) 的抑制剂，可用于慢性炎症性肾脏疾病的研究。
PC54659	CAY10594	1130067-34-3	CAY10594 是一种有效的磷脂酶 D2 (PLD2) 抑制剂(体外 IC50=140 nM，细胞 IC50=110 nM)。CAY10594 在体外高度抑制乳腺癌细胞的侵袭性迁移，并通过调节磷酸化 GSK-3β/JNK 轴改善扑热息痛诱导的急性肝损伤。
PC54421	CAY10650	1233706-88-1	CAY10650 是一种高效的胞浆磷脂酶A2α (cPLA2α) 抑制剂，IC50 值为 12 nM。CAY10650 抑制脂滴形成和 PGE2 分泌。
PL09747	CCT129957	883098-58-6	CCT129957 是一种吲哚衍生物，也是一种有效的磷脂酶 C-γ (PLC-γ) 抑制剂，IC50 为 ~3 μM，GC50 为 15 μM。CCT129957 以约 15 μM 的浓度抑制鳞状细胞中 Ca<sup>2+</sup> 的释放。
PL09423	Compound 48/80 trihydrochloride	848035-21-2	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。
PC12581	CP 316819	186392-43-8	选择性糖原磷酸化酶抑制剂
PC12531	CP-91149	186392-40-5	糖原磷酸化酶选择性抑制剂,CP-91149 是 GP (糖原磷酸化酶) 的抑制剂。CP-91149 促进糖原的重新合成，但不导致糖原的过度积累。CP-91149 有用于2型糖尿病研究的潜能。
PL09746	DPTIP	351353-48-5	DPTIP 是有效的、可透过血脑屏障的中性鞘磷脂酶 (N-SMase 2) (外泌体抑制剂)，其 IC50 值为 30 nM。
PC12778	EA4	389614-94-2	rPLA2抑制剂，Ki: 130 μM，EA4 is a rPLA2 inhibitor.rPLA2, a calcium-dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells. With a molecular mass of 42 kDa, cPLA2 shows biochemical properties
PL09741	Ecopladib	381683-92-7	Ecopladib 是一种胞浆磷脂酶 A2α (phospholipase A2α) 抑制剂，在 GLU micelle 和大鼠全血细胞中，IC50 值分别为 0.15 μM 和 0.11 μM。
PC12661	Edelfosine	77286-66-9	抑制磷脂酰肌醇磷脂酶C，Edelfosine is a synthetic lysophospholipid analog that selectively inhibits PLC with IC50 of 9.6 uM in fibroblasts and adenocarcinoma cells.
PC12670	FIPI	939055-18-2	磷脂酶D（PLD）抑制剂，FIPI 是 halopemide 的衍生物，能够有效抑制 PLD1 和 PLD2，IC50 值分别为 25 nM 和 20 nM。
PL09740	GK187	1071001-50-7	GK187 是一种有效且具有选择性的 Group VIA 钙非依赖性磷脂酶A2 (GVIA iPLA2) 抑制剂，XI(50)值为0.0001。GK187可用于各种神经疾病的研究。