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Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), a member of the serine protease family, which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain, has high activity in the liver. Accumulated evidence suggests that PREP participates in physiological and pathological processes, including maturation and degradation of peptides, inflammation, oxidative stress, autophagy, cell proliferation and cancer.
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