Endogenous Metabolite

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Endogenous Metabolite 相关产品（3）

货号	产品名	Cas	产品描述
PC61706	27-Hydroxycholesterol	20380-11-4	27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。
PC22088	Glycohyocholic acid	32747-08-3	Glycohyocholic acid(GHCA) 是原代胆汁酸-甘氢胆酸的甘氨酸结合形式。
PC14879	Tretinoin (Aberela).	302-79-4	视黄酸,用于治疗痤疮和毛发角化病.Retinoic acid是维生素A的代谢产物，在细胞生长，分化和器官发生中起重要作用。 Retinoic acid是RAR 核受体的天然激动剂，对RARα/β/γ的 IC50 为14 nM。 Retinoic acid与 PPARβ/δ 结合的 Kd 值为17 nM。