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Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. There are two types of apoptotic caspases: initiator (apical) caspases and effector (executioner) caspases. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them. Effector caspases (e.g., CASP3, CASP6, CASP7) in turn cleave other protein substrates within the cell, to trigger the apoptotic process. The initiation of this cascade reaction is regulated by caspase inhibitors. CASP4 and CASP5, which are overexpressed in some cases of vitiligo and associated autoimmune diseases caused by NALP1 variants, are not currently classified as initiator or effector in MeSH, because they are inflammatory enzymes that, in concert with CASP1, are involved in T-cell maturation.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PL20178 | 非扎奴单抗 | 1007106-86-6 | Fezakinumab 是一种有效的白细胞介素 22 (IL-22) 单克隆抗体。Fezakinumab 可用于研究银屑病、类风湿性关节炎和特应性皮炎等免疫系统疾病和炎症相关疾病。 |
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