胰岛素受体

Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin. The receptor is a disulfide-linked oligomer comprised of two alpha and two beta subunits. The insulin receptor exists in two isoforms, IR-A and IR-B, expressed in different relative abundance in the various organs and tissues. The two IR isoforms have similar binding affinity for insulin but different affinity for insulin-like growth factor (IGF)-2 and proinsulin, which are bound by IR-A but not IR-B.

The insulin receptor has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels. Insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and Alzheimer's disease.

胰岛素受体相关产品（5）

货号	产品名	Cas	产品描述
PC16149	Demethylasterriquinone B1	78860-34-1	胰岛素受体（IR）激活剂
PC16164	HNGF6A	1093111-54-6	增加葡萄糖刺激的胰岛素分泌和葡萄糖代谢,HNGF6A 是一种人类素类似物。HNGF6A 可以增加葡萄糖刺激的胰岛素分泌和葡萄糖代谢，并可用于糖尿病的研究。HNGF6A 在氧化应激期间抑制 ROS 的产生。HNGF6A 可以在体内预防内皮功能障碍和动脉粥样硬化。
PC16196	HNMPA	132541-52-7	细胞非渗透性酪氨酸激酶抑制剂,HNMPA is a tyrosine kinase inhibitor that inhibited both the receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity [1].
PC16036	KU14R	189224-48-4	I(3)-R拮抗剂,KU14R是胰岛素受体拮抗剂，能选择性阻断由咪唑啉引起的胰岛素分泌。
PC16160	人胰岛素	11061-68-0	内源性胰岛素受体激动剂,Insulin(human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。

胰岛素受体

胰岛素受体 相关产品（5）

胰岛素受体相关产品（5）