法尼基转移酶

Farnesyl transferase is a zinc-dependent enzyme that catalyzes the attachment of a farnesyl lipid group to the sulfur atom of a cysteine residue of numerous proteins involved in cell signaling including the oncogenic H-Ras protein. Farnesyl transferase regulates the activation of Ras protein and consequently affects intracellular signal transduction, cell growth and proliferation.

Farnesyl transferase is an essential enzyme at downstream of mevalonate (MVA) pathway. Farnesyl transferase catalyzes the farnesylmoieties of farnesyl pyrophosphate (FPP) coupled to Ras protein, which is dependent on farnesylation anchoring itself in membrane for its activity. Farnesyl transferase inhibitors are small-molecule inhibitors that selectively inhibit farnesylation of a number of intracellular substrate proteins such as Ras. Farnesyl transferase inhibitors represent a new class of agents that target signal transduction pathways responsible for the proliferation and survival of diverse malignant cell types.

法尼基转移酶相关产品（13）

货号	产品名	Cas
PL13904	ABT-100	450839-40-4
PL13908	BMS-214662	195987-41-8
PL13906	CP-609754	1190094-64-4
PL13909	FGTI-2734	1247018-19-4
PL13907	FGTI-2734 mesylate	2702297-24-1
PL13902	FTI 276	170006-72-1
PL13905	FTI-2153	344900-92-1
PL13901	FTI-2153 TFA
PC54320	FTI-276 (trifluoroacetate salt)	1217471-51-6
PL10892	FTI-277 hydrochloride	180977-34-8
PL13910	L-778123 hydrochloride	253863-00-2
PL13911	LB42708	226929-39-1
PL13903	Tipifarnib (S enantiomer)	192185-71-0

法尼基转移酶

法尼基转移酶 相关产品（13）

法尼基转移酶相关产品（13）