Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
货号 | 产品名 | Cas | 产品描述 |
---|---|---|---|
PC54761 | DL-AP3 | 5652-28-8 | DL-AP3 是一种竞争性的 mGluR1 和 mGluR5 拮抗剂。DL-AP3 也是磷酸丝氨酸磷酸酶 (phosphoserine phosphatase) 的抑制剂。DL-AP3具有神经保护作用。 |
PC12733 | ML-095 (hydrochloride) | 1135318-57-8 | 胎盘碱性磷酸酶(PLAP)抑制剂,ML-095 (hydrochloride) is a specific PLAP inhibitor [1]. |
PC12692 | Sodium molybdate | 7631-95-0 | 酸性和磷蛋白磷酸酶抑制剂,Sodium molybdate是钼酸的有用来源。常用的为钼酸钠二水合物。 |
PC12693 | Sodium tartrate | 868-18-8 | 酸性磷酸酶抑制剂,螯合剂;酸味调整剂;缓冲剂;乳化盐;抗氧化剂;抗氧化增效剂。 |
PC12694 | ★Imidazole | 288-32-4 | 碱性磷酸酶抑制剂,Imidazole是一种平面五元环, 是一种高极性化合物, 已被广泛用作腐蚀抑制剂 |