SIKs

Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and functions mainly involve in regulating energy response-related physiological processes, such as gluconeogenesis and lipid metabolism. The SIK family comprises three isoforms, namely, SIK1, SIK2, and SIK3, all of which may act as metabolic transmitters. SIKs have shown self-phosphorylation, and play an important role in regulating adrenocortical function under the stimulation of high salt or adreno-cortico-tropic-hormone (ACTH).

All three SIK family kinases are expressed broadly. SIK1 mRNA expression is regulated by multiple stimuli, including high dietary salt intake, ACTH signaling, glucagon signaling, excitable cell depolarization, and circadian rhythms. In contrast, SIK2 and SIK3 expression is constitutive in tissues in which these kinases are expressed. In humans, SIK2 and SIK3 are expressed ubiquitously, with highest SIK2 levels in adipose tissue and highest SIK3 expression in brain. In addition, these SIK family members are dysregulated in various cancers, including ovarian, breast, prostate, and lung cancers, indicating that SIKs may execute crucial roles in tumor occurrence or progression.

SIKs 相关产品（9）

货号	产品名	Cas
PL11111	ARN-3236	1613710-01-2
PL06951	DB1113	2769753-53-7
PC11546	HG-9-91-01	1456858-58-4
PL08773	MRIA9
PL11110	MRT199665	1456858-57-3
PL11107	WH-4-025	1876463-35-2
PL11112	YKL-05-099	1936529-65-5
PL11109	YKL-06-061	2172617-15-9
PL11108	YKL-06-062	2172617-16-0