Toll样受体(TLR)

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals. TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection. TLRs recognize highly conserved structural motifs known as pathogen-associated microbial patterns (PAMPs), which are exclusively expressed by microbial pathogens.

Toll样受体(TLR) 相关产品（92）

货号	产品名	Cas	产品描述
PL12308	1V209	1062444-54-5
PL12347	ABR-238901	1638200-22-2
PL12346	Afimetoran	2171019-55-7
PL12297	AN-3485	1213827-99-6
PL12317	AT791	1219962-49-8
PL12336	AXC-715 trihydrochloride	2479276-17-8
PL12305	AZD8848	866269-28-5
PL12350	C29	363600-92-4
PL08877	Chloroquine	54-05-7	Chloroquine 是一种广泛用于疟疾和类风湿性关节炎的抗炎试剂。Chloroquine 是自噬 (autophagy) 和 Toll 样受体 (TLRs) 的抑制剂。Chloroquine 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC50=1.13 μM)。
PL11175	Chloroquine-d5	1854126-41-2
PL12314	CL075	256922-53-9
PL10948	CL097	1026249-18-2
PL12334	CL097 hydrochloride
PL12342	CL264	1510712-69-2
PC11573	CU CPT 22.	1416324-85-0
PC11572	CU CPT 4a	1279713-77-7
PL12340	CU-115	2471982-20-2
PL12309	CU-CPT-8m	125079-83-6
PL12344	CU-CPT-9a	2165340-32-7
PL12310	CU-CPT17e	2109805-75-4