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1V209

(Synonyms: TLR7 agonist T7)

目录号: PL12308 纯度: ≥99%

1V209 (TLR7 agonist T7) 是 Toll-like receptor 7 (TLR7) 激动剂，具有抗肿瘤作用。1V209 可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性。

CAS No. :1062444-54-5

商品编号	规格	价格	会员价
PL12308-5mg	5mg	¥492.00	请登录
PL12308-10mg	10mg	¥787.00	请登录
PL12308-25mg	25mg	¥1625.00	请登录
PL12308-50mg	50mg	¥2375.00	请登录
PL12308-100mg	100mg	¥3365.00	请登录
PL12308-200mg	200mg	¥4595.00	请登录
PL12308-500mg	500mg	询价	询价
PL12308-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2475.00	请登录
PL12308-1 mL x 10 mM (in DMSO)		¥388.00	请登录

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中文名称	1V209
英文名称	1V209
英文别名	1V209;AOB1245;ATISKRYGYNSRNP-UHFFFAOYSA-N;4-[6-amino-8-hydroxy-2-(2-methoxyethoxy)purin-9-ylmethyl]benzoic acid;4-((6-Amino-2-(2-methoxyethoxy)-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl)benzoic acid;4-[[6-Amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9-yl]methyl]benzoic acid;TLR7 agonist T7;1V209 (TLR7 agonist T7);BDBM50539339;D81253;4-[[6-Amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-benzoic acid
Cas No.	1062444-54-5
分子式	C₁₆H₁₇N₅O₅
分子量	359.34
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	1V209 (TLR7 agonist T7) 是 Toll-like receptor 7 (TLR7) 激动剂，具有抗肿瘤作用。1V209 可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性。

产品详情	1V209 (TLR7 agonist T7) 是 Toll-like receptor 7 (TLR7) 激动剂，具有抗肿瘤作用。1V209 可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性。
生物活性	1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity.
性状	Solid
IC50 & Target[1][2]	TLR7
体外研究(In Vitro)	1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells. 1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Battistella C, et al. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 Dec;8(23):e1901105. [2]. Shinchi H, et al. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19;26(8):1713-23.

溶解度数据	In Vitro: DMSO : 83.33 mg/mL (231.90 mM; Need ultrasonic)配制储备液

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[1]. Battistella C, et al. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 Dec;8(23):e1901105.
[2]. Shinchi H, et al. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19;26(8):1713-23.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

1V209

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