Gonadotropin-Releasing Hormone Receptors

The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.

Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the G_q/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.

Gonadotropin-Releasing Hormone Receptors 相关产品（3）

货号	产品名	Cas	产品描述
PC11273	AG 045572	263847-55-8	GnRH拮抗剂,AG 045572也称为CMPD1，是促性腺激素释放激素（GnRH）的非肽类拮抗剂[1]，对人类和小鼠GnRH受体的Ki值分别为6.0 nM和2.2 nM [
PC11249	T 98475	199119-18-1	促性腺激素释放激素（GnRH，LHRH）受体拮抗剂，口服活性
PC11354	WAY 207024 dihydrochloride	872002-73-8	GnRH-R拮抗剂,WAY 207024 dihydrochloride是一种有效的促性腺激素释放激素受体（GnRH-R）拮抗剂，作用于人和大鼠的GnRH受体，IC50值分别为12和71 nM[1]。