Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis. Acetyl-CoA carboxylase has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer, and other diseases.

In animals, there are two major isoforms of ACCs, ACC1, and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution. The first committed step of fatty acid synthesis (FASyn) is mediated by ACC, which in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks carnitine palmitoyltransferase-1 (CPT-1) function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Acetyl-CoA Carboxylase 相关产品（11）

货号	产品名	Cas	产品描述
PL04385	Acetyl-CoA Carboxylase-IN-1	179343-23-8	Acetyl-CoA Carboxylase-IN-1 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂，IC50 值为＜5 nM。 Acetyl-CoA Carboxylase-IN-1 具有抗菌活性。
PL03538	CMS-121	1353224-53-9	CMS-121 是一种喹诺酮衍生物，也是一种口服活性的乙酰辅酶 A 羧化酶 1 (acetyl-CoA carboxylase 1, ACC1) 抑制剂。CMS-121 分别以 EC50 值为 7 nM 和 200 nM 来保护 HT22 细胞免受缺血和氧化损伤。CMS-121 具有强大的神经保护，抗炎，抗氧化和肾保护作用。
PL04394	CP-640186 hydrochloride	591778-70-0	CP-640186 hydrochloride 是一种具有口服活性的、可透过细胞的乙酰-CoA 羧化酶 (ACC) 抑制剂，其对大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50s 分别为 53 nM 和 61 nM。乙酰-CoA羧化酶 (ACC) 是脂肪酸代谢的一个关键酶，能够合成丙二酰-CoA。CP-640186 hydrochloride 还可以刺激肌肉脂肪酸的氧化。
PL04675	Firsocostat	1434635-54-7	Firsocostat (ND-630; GS-0976; NDI-010976) 是乙酰辅酶A羧化酶 (ACC) 抑制剂，抑制人类 ACC1 和 ACC2 的 IC50 值分别为2.1和6.1 nM。
PL04676	Firsocostat (S enantiomer)		Firsocostat S enantiomer (ND-630 S enantiomer) 是 Firsocostat 的低活性的 S 型异构体。Firsocostat 是乙酰辅酶 A 羧化酶抑制剂。
PL05565	Fluazifop-P-butyl	79241-46-6	Fluazifop-P-butyl 是一种来自芳基苯氧基丙酸酯的杀草剂，是一种乙酰辅酶 A 羧化酶 (ACCase) 抑制剂。
PL05560	Haloxyfop	69806-34-4	Haloxyfop 是一种芳氯氧苯氧丙酸除草剂 (herbicide)，广泛应用于阔叶作物的野草。Haloxyfop 对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 的抑制作的 IC50 为 0.5 μM，而对豌豆中该酶无影响。
PL01627	MK-4074	1039758-22-9	MK-4074是乙酰辅酶A羧化酶 (acetyl-CoA carboxylase) 的肝特异性抑制剂，IC50 值约为3nM。
PL01297	ND-646	1434639-57-2	ND-646 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂，抑制重组 hACC1 和 hACC2，IC50 分别为 3.5 nM 和 4.1 nM。
PL04766	Olumacostat glasaretil	1261491-89-7	Olumacostat glasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。
PL03048	PF-05175157	1301214-47-0	PF-05175157 是一种广谱乙酰辅酶 A 羧化酶 (ACC) 抑制剂，对 ACC1 (human)，ACC2 (human)， ACC1 (rat) 和 ACC2 (rat) 的 IC50 值分别为 27.0, 33.0, 23.5 和 50.4 nM。