CD73

CD73 (Ecto-5′-nucleotidase) is a 70-kD glycosylphosphatidyl inositol (GPI)-anchored cell surface protein encoded by the NT5E gene that plays a crucial role in switching on adenosinergic signaling. CD73 is an ectonucleotidase which catalyzes the terminal step in extracellular adenine nucleotide breakdown: the conversion of AMP to adenosine. Adenosine, which binds to a discrete family of cell surface receptors to initiate intracellular signaling cascades, has been shown to be anti-inflammatory and vasorelaxant.

CD73 has both enzymatic and non-enzymatic functions in cells: as a nucleotidase, CD73 catalyzes the hydrolysis of AMP into adenosine and phosphate, and CD73-generated adenosine plays an important role in tumor immunoescape; moreover, CD73 also functions as a signal and adhesive molecule that can regulate cell interaction with extracellular matrix components, such as laminin and fibronectin, to mediate the invasive and metastatic properties of cancers. Both the enzymatic and non-enzymatic functions of CD73 are involved in cancer-associated processes and are not completely independent of each other. There is ample evidence to show that CD73 is a key regulatory molecule in cancer development and is overexpressed in many cancers, including leukemia, glioblastoma, melanoma, ovarian cancer, esophageal cancer, prostate cancer and breast cancer.

CD73 相关产品（13）

货号	产品名	Cas	产品描述
PL02750	AB-680	2105904-82-1	AB-680 是一种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂，对 hCD73 的 Ki 值为 4.9 pM，对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性。
PL01454	CD73-IN-1	2132396-40-6	CD73-IN-1 是 CD73 的抑制剂，可用于癌症的研究，来自专利 WO 2017153952 A1，实例 80。
PL03661	CD73-IN-3	2375815-63-5	CD73-IN-3 是一种有效的 CD73 抑制剂(IC50; Calu6 人细胞实验中)。CD73-IN-3，例 2 源自专利 WO2019168744 A1，具有研究癌症的潜力。
PL03254	CD73-IN-4	2216764-29-1	CD73-IN-4 是一种高效、选择性的亚甲基膦酸 CD73 抑制剂，对人 CD73 作用的 IC50 值为 2.6 nM。CD73-IN-4 在癌症免疫学研究中具有潜在的应用价值。
PL04074	CD73-IN-5	2412019-99-7	CD73-IN-5 是一种有效且选择性的非核苷酸小分子 CD73 抑制剂（IC50 = 19 nM）。
PL02049	MethADP	3768-14-7	MethADP 是一个特异性的 CD73 抑制剂。
PL02050	MethADP triammonium		MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium 是一种 CD73 抑制剂。MethADP 可用于 ATP-腺苷通路的研究。
PL06050	Mupadolimab	2451856-97-4	Mupadolimab (CPI-006) 是一种 IgG1κ 人源化的 FcγR 结合缺陷抗 CD73 单抗，激活 CD73<sup>POS</sup> B 细胞。
PL06015	Oleclumab	1803176-05-7	Oleclumab (MEDI9447) 是一种人 IgG1λ 抗 CD73 单克隆抗体，可抑制 CD73 功能。Oleclumab 具有抗肿瘤活性。
PL03649	OP-5244	2381268-71-7	OP-5244 是一种有效和具有口服活性的 CD73 抑制剂，IC50 值为 0.25 nM。OP-5244 通过阻断腺苷的产生来逆转免疫抑制作用，具有进行癌症研究的潜力。
PL03650	OP-5244 sodium		OP-5244 sodium 是一种有效和具有口服活性的 CD73 抑制剂，IC50 值为 0.25 nM。OP-5244 sodium 通过阻断腺苷的产生来逆转免疫抑制作用，具有进行癌症研究的潜力。
PL01122	PSB-12379	1802226-78-3	PSB-12379 是一种核苷酸类似物，是一种有效的 Ecto-5'-Nucleotidase (CD73) 抑制剂，Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。
PL06047	Uliledlimab	2378407-27-1	Uliledlimab 是一种有效的抗 CD73 人源单克隆抗体。Uliledlimab 抑制胞外单磷酸腺苷 (AMP) 向腺苷的转化。Uliledlimab 可用于癌症的研究。