NFAT

Nuclear factor of activated T cells (NFAT) proteins are a family of Ca²⁺/calcineurin-dependent transcription factors that were initially identified as inducible nuclear factors that could bind the interleukin-2 (IL-2) promoter in activated T cells. However, when all of the proteins of the NFAT family had been isolated and molecularly characterized, it became clear that their expression was not limited to T cells. Recent work has uncovered new regulatory roles for NFAT proteins in diverse organs, including the central nervous system, blood vessels, heart, kidney, bone, skeletal muscle and haematopoietic stem cells. For examples, cells in the vessel wall display a diverse array of Ca²⁺ signaling modalities, which are subject to change during disease. The fact that NFAT proteins are able to decode and translate these signals into changes in gene expression makes them potential regulators of vascular pathogenesis.

NFAT 相关产品（5）

货号	产品名	Cas	产品描述
PL07883	11R-VIVIT TFA		11R-VIVIT TFA 是一种活化 T 细胞的细胞通透性核因子 (NFAT) 抑制剂。11R-VIVIT TFA 可用于足细胞和糖尿病肾病的研究。
PL07882	KRM-III	79220-94-3	KRM-III 是一种有效的具有口服活性的 T 细胞抗原受体 (TCR) 抑制剂。KRM-III 抑制 TCR 和肉豆蔻酸乙酸酯/佛波霉素/离子霉素诱导的 NFAT 核因子活化和 T 细胞增殖，IC50 约为 5 μM。抗炎活性。
PL07886	KRN2 bromide	1390654-28-0	KRN2 bromide 是选择性的 T 细胞激活核因子 (NFAT5) 的抑制剂，IC50 值为 100 nM。KRN2 bromide 有潜力用于 NFAT5-介导的慢性关节炎的潜能。
PL07884	KRN5	1800465-47-7	KRN5 是 KRN2 的衍生物，是具有口服活性的 T 细胞激活核因子 (NFAT5) 的抑制剂，IC50 值为 750 nM。KRN5 有潜力用于 NFAT5-介导的慢性关节炎的研究。
PL07885	Q134R	2022949-46-6	Q134R，一种神经保护性羟基喹啉衍生物，可抑制活化 T 细胞 (NFAT) 信号的核因子。Q134R 可以穿过血脑屏障，并可用于阿尔茨海默病 (AD) 和衰老相关疾病的研究。