SCD

Stearoyl-CoA desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a model for selective degradation of short-lived proteins of the endoplasmic reticulum (ER). SCD is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Both contribute a major part of the biological membrane. Numerous SCD isoforms exist in mouse and humans, i.e., SCD-1 to SCD-4 and SCD-1 and SCD-5, respectively.

Overexpression of SCD is evident and implicated in metabolic diseases such as diabetes and non-alcoholic fatty liver disease. SCD also stimulates canonical Wnt pathway and YAP activation in support of stemness and tumorigenesis. SCD facilitates metabolic reprogramming in cancer which is mediated, at least in part, by regulation of AKT, AMPK, and NF-kB via MUFAs. From the biological viewpoint, hyperexpression of SCD1 causes many metabolic disorders including obesity, insulin resistance, hypertension, and hypertriglyceridemia, etc. SCD1 is a pharmacological target in the treatment of obesity, diabetes and other metabolic diseases.

SCD 相关产品（16）

货号	产品名	Cas
PC12560	A939572	1032229-33-6
PC54328	CAY10566	944808-88-2
PL11506	CVT-11127	1018674-83-3
PL11505	CVT-12012	1018675-35-8
PL11502	GSK1940029	1150701-66-8
PL11504	Icomidocholic acid	246529-22-6
PL11503	MF-438	921605-87-0
PL11507	MK-8245	1030612-90-8
PL11497	MK-8245 Trifluoroacetate	1415559-41-9
PL11501	SCD1 inhibitor-1	1069094-65-0
PL11496	SCD1 inhibitor-3	1282606-48-7
PL11499	SCD1 inhibitor-4	1295541-87-5
PC12718	SW203668	1673556-40-5
PL11498	T-3764518	1809151-56-1
PL11500	XEN723	1072803-08-7
PL11495	YTX-465	2225824-53-1