Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Porcupine 相关产品（5）

货号	产品名	Cas	产品描述
PL09924	ETC-159	1638250-96-0	ETC-159 (ETC-1922159) 是有效的，具有口服活性的 PORCN 抑制剂。抑制β-catenin报告基因活性的 IC50 值为2.9 nM。
PL09922	GNF-6231	1243245-18-2	GNF-6231是一个强的，有选择性的，能够口服的Porcupine抑制剂能够阻止Wnt信号通路。
PL09923	IWP L6	1427782-89-5	IWP L6 (Porcn Inhibitor III) 是高活性 Porcn 抑制剂，EC50 为 0.5 nM。
PL09921	IWP-O1	2074607-48-8	IWP-O1 是一个有效的 Porcn 抑制剂，在 L-Wnt-STF 细胞中的 EC50 值为 80 pM。IWP-O1 抑制 Wnt 蛋白分泌。IWP-O1 能够抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。
PL09920	Porcn-IN-1	2036044-77-4	Porcn-IN-1 是有效的 porcupine 抑制剂，IC50 值为 0.5±0.2 nM。