PKD

PKD (Protein kinase D) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. PKD family of serine/threonine protein kinases has three members: PKD1, PKD2, PKD3. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity.

PKD 相关产品（4）

货号	产品名	Cas	产品描述
PL09909	3-IN-PP1	2227110-54-3	3-IN-PP1 是一种蛋白激酶 D (PKD) 抑制剂。 3-IN-PP1 对 PKD1、PKD2 和 PKD3 具有有效广泛的 PKD 抑制活性， IC50 值分别为 108、94 和 108 nM。3-IN-PP1 也是一种广谱抗癌剂，对多种肿瘤细胞的生长有抑制作用。3-IN-PP1 可用于癌症研究。
PL09911	CID755673	521937-07-5	CID755673是高效选择性的PKD1抑制剂，IC50 of 值为182 nM。
PL09912	CRT0066101 dihydrochloride	1883545-60-5	CRT0066101 dihydrochloride是有效，选择性的 PKD 抑制剂，对PKD1，2和3的IC50值分别为1，2.5和2 nM。
PL09910	kb NB 142-70	1233533-04-4	kb NB 142-70 是一种有效的 PKD 抑制剂，对 PKD1，PKD2 和 PKD3 的 IC50 值分别为 28.3 nM，58.7 nM 和 53.2 nM；kb NB 142-70 同时具有抗肿瘤活性。