BTK

Bruton tyrosine kinase (Btk) is a member of the Tec family kinases with a well-characterized role in B-cell antigen receptor (BCR)-signaling and B-cell activation.

Btk plays a crucial role in B cell development and activation through the BCR signaling pathway and represents a new target for diseases characterized by inappropriate B cell activity. Btk is a kinase expressed exclusively in B cells and myeloid cells and has a well characterized, vital role in B cells highlighted by the human primary immune deficiency disease, X-linked agammaglobulinemia (XLA), which results from mutation in the Btk gene. Btk plays an essential role in the BCR signaling pathway. Antigen binding to the BCR results in B cell receptor oligomerization, Syk and Lyn kinase activation, followed by Btk kinase activation. Once activated, Btk forms a signaling complex with proteins such as BLNK, Lyn, and Syk and phosphorylates phospholipase C (PLC)γ2. This leads to downstream release of intracellular Ca²⁺ stores and propagation of the BCR signaling pathway through extracellular signal-regulated kinase and NF-κB signaling, ultimately resulting in transcriptional changes to foster B cell survival, proliferation, and/or differentiation.

BTK 相关产品（59）

货号	产品名	Cas
PL01763	(R)-Elsubrutinib	1643570-23-3
PL03218	(R)-Pirtobrutinib	2101700-14-3
PL01233	(R)-Zanubrutinib	1691249-44-1
PL03131	(Rac)-IBT6A	1412418-47-3
PL03319	(S)-Sunvozertinib	2370013-49-1
PL01231	(±)-Zanubrutinib	1633350-06-7
PL04750	Acalabrutinib	1420477-60-6
PL04751	Acalabrutinib-d4	2699608-18-7
PL03454	ACP-5862	2230757-47-6
PL02016	ARQ 531	2095393-15-8
PL04314	BI-1622	2681392-19-6
PL03223	BIIB068	1798787-27-5
PL03893	BIIB091	2247614-80-6
PL04022	BLK-IN-2	2694871-86-6
PL01287	BMS-935177	1231889-53-4
PL01303	BMS-986142	1643368-58-4
PL02004	Branebrutinib	1912445-55-6
PL01312	BTK IN-1	1270014-40-8
PL02781	BTK inhibitor 10	2241732-30-7
PL03237	BTK inhibitor 17	1858206-76-4