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REV-ERB is a member of the nuclear receptor superfamily consisting of two similar proteins: REV-ERBα and REV-ERBβ. REV-ERBα and REV-ERBβ, are encoded by Nr1d1 and Nr1d2, and link circadian rhythms and metabolism. REV-ERBs lack the canonical NR activation domain, and thus function as a transcriptional repressor. Like other NRs, REV-ERBs can be regulated by ligands, including naturally occurring heme (22, 23), which modulate their repressive activity. Two REV-ERB molecules, usually present as a dimer, compete with retinoic acid receptor-related orphan receptor (ROR) for the binding to the ROR response element DNA sequence (RORE) region. REV-ERB is involved in the regulation of many physiological processes, from circadian rhythm, to immune function and metabolism. Accordingly, REV-ERB has been considered as a promising, but difficult drug target for the treatment of numerous diseases.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PL10976 | SR10067 | 1380548-02-6 | |
| PL10975 | SR9011 hydrochloride | 2070014-94-5 | |
| PL10974 | STL1267 | 1429024-58-7 |
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