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Autophagy-targeting chimera (AUTAC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. One end of AUTAC is target protein ligand, the other end is a site of K63 ubiquitin modification, and the two parts are connected by linker. AUTAC induces recognition of LC3 receptors of autophagosomes by K63-linked polyubiquitination and then the Target-AUTAC complex was phagocytosed and transferred into lysosomal for degradation.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PL03413 | AUTAC4 | 2267315-04-6 | |
| PL04334 | TSPO ligand-2 | 1160640-95-8 |
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