Autophagy-targeting chimera (AUTAC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. One end of AUTAC is target protein ligand, the other end is a site of K63 ubiquitin modification, and the two parts are connected by linker. AUTAC induces recognition of LC3 receptors of autophagosomes by K63-linked polyubiquitination and then the Target-AUTAC complex was phagocytosed and transferred into lysosomal for degradation.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PL03413 | AUTAC4 | 2267315-04-6 | AUTAC4 是一种靶向线粒体的自噬靶向嵌合体 (AUTAC)。AUTAC4 下调细胞质蛋白并通过线粒体自噬促进靶向线粒体更新。 |
| PL04334 | TSPO ligand-2 | 1160640-95-8 | TSPO ligand-2 是 AUTAC1 的配体。AUTAC1 含有一个 p-氟苄基鸟嘌呤 (FBnG) 和一个烟霉醇，可沉默 HeLa 细胞中的 MetAP2 蛋白。 |
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