TGF-β Receptor（TGF-β受体）

TGF-β receptors (Transforming growth factor-β receptors) are single pass serine/threonine kinase receptors. Transforming growth factor beta (TGF-beta) is a member of a large family of pleiotropic cytokines that are involved in many biological processes, including growth control, differentiation, migration, cell survival, adhesion, and specification of developmental fate, in both normal and diseased states. TGF-beta superfamily members signal through a receptor complex comprising a type II and type I receptor, both serine/threonine kinases.

The type I receptors, referred to as activin receptor-like kinases (ALK), lie at the epicenter of the signaling cascade as they transduce TGF-beta signals to intracellular regulators of transcription known as Smad proteins. ALKs possess an extracellular binding domain, a transmembrane domain, a GS domain that serves as the site of activation by type II receptors, and a kinase domain that activates downstream signaling molecules. ALKs mediate the effect of TGF-beta superfamily on a variety of cellular processes such as proliferation, differentiation, apoptosis, adhesion and migration, and therefore play important roles in many biological processes. Some ALKs have been implicated in several disorders, including tumorigenesis and immune diseases, suggesting that these receptors can be used as drug targets.

TGF-β Receptor（TGF-β受体）相关产品（402）

货号	产品名	Cas
PL08591	(22S,23S)-Homobrassinolide	80483-89-2
PL11630	(24S)-MC 976	112849-14-6
PL09434	(R,R)-BD-AcAc 2	1208313-97-6
PL11831	1-Cyclohexyl-3-dodecyl urea	402939-18-8
PL11781	10,12-Tricosadiynoic acid	66990-30-5
PL11663	123C4	2034159-30-1
PL11525	2',3'-cGAMP sodium
PL11828	2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid	413624-71-2
PL11739	2-Methylcitric acid trisodium	117041-96-0
PL11632	24, 25-Dihydroxy VD2	58050-55-8
PL11639	3,3-Dimethyl-1-butanol	624-95-3
PL08590	3,4,5-Trihydroxycinnamic acid decyl ester	1770778-45-4
PL11688	3,5-Dihydroxyacetophenone	51863-60-6
PL11784	3-Hydroxybutyric acid sodium	150-83-4
PL08402	3β-Ursodeoxycholic acid	78919-26-3
PL11735	4-Methyl-1-phenyl-2-pentanone	5349-62-2
PL08595	5'-Phosphoguanylyl-(3',5')-guanosine	33008-99-0
PL11610	[Des-His1,Glu9]-Glucagon amide TFA
PL11863	A 83-01 sodium
PL11755	AC-262536	870888-46-3

TGF-β Receptor（TGF-β受体）

TGF-β Receptor（TGF-β受体） 相关产品（402）

TGF-β Receptor（TGF-β受体）相关产品（402）