KLF

Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. KLFs can be deregulated in multiple cancers either by loss of heterozygosity (LOH), somatic mutation or transcriptional silencing by promoter hypermethylation.

KLF family member proteins play a critical role in the growth and metastasis of numerous tumor types, at least in part by regulating the expression of cell cycle genes. Globally, KLF4 and KLF6 are considered as tumor suppressor gene, whereas KLF5 promotes cell proliferation. Family members have different transcriptional properties and can modulate each other's activity by a variety of mechanisms. Since cells can express multiple KLFs, KLF transcription factors build likely a transcriptional network to control cell proliferation. Effects of changes in KLF factors are context-dependent and can appear contradictory, considering differences in the expression profile of family members in various cells. Last, KLF variants may antagonize the function of wild type proteins.

KLF 相关产品（3）

货号	产品名	Cas	产品描述
PL04602	APTO-253	916151-99-0	APTO-253 (LOR-253) 是一种小分子，可抑制c-Myc表达，稳定 G-四链体 DNA 并诱导急性髓样白血病细胞的细胞周期停滞和凋亡。APTO-253 通过诱导 Kruppel-like factor 4 (KLF4) 抑癌因子介导抗癌活性。APTO-253 具有抗关节炎活性。
PL03873	SR15006	2505001-54-5	SR15006 是 Kruppel-like factor 5 (KLF5) 的抑制剂剂 (在 DLD-1 CRC 细胞的中，IC50 = 41.6 nM)。
PL03608	SR18662	2505001-62-5	SR18662 是一种有效的 Kruppel-like factor 5 (KLF5) 的抑制剂， IC50 为 4.4 nM，ML264 (HY-19994) 的类似物。SR18662 可用于结直肠癌的相关研究。