JNK

JNK (c-Jun N-terminal kinase), a kinase subfamily belonging to the MAPK, is activated in response to various stress stimuli and possesses a wide variety of regulatory functions. The JNK family of serine/threonine protein kinases comprises three isoforms (JNK1, JNK2 and JNK3). JNKs are involved in the emergence and progression of diverse pathologies such as neurodegenerative, cardiovascular and metabolic disorders as well as inflammation and cancer.

Similar to the other MAP kinases, JNKs are activated by a phosphorylation cascade generally involving two types of upstream kinases, the so-called MAP kinase kinase kinases (MAP3K, MKKK) and the MAP kinase kinases (MAP2K; MKK). At the MAP2K level, JNKs are activated by MKK4 and MKK7, the former is a common activator of the JNK and the p38 MAP kinase signaling pathway. The JNK cascade shares various intersection points with other pathways making it a part of a complex signaling network.

JNK 相关产品（32）

货号	产品名	Cas
PC11832	AEG 3482	63735-71-7
PC11804	Anisomycin	22862-76-6
PC11747	AS 602801	848344-36-5
PC11833	BI 78D3	883065-90-5
PC11780	CC-401	395104-30-0
PC11750	CC-401 hydrochloride	1438391-30-0
PL03735	CC-90001	1403859-14-2
PC11816	CEP 1347	156177-65-0
PL05748	D-JNKI-1	1445179-97-4
PC11754	DB07268	929007-72-7
PC11788	DTP3	1809784-29-9
PL01088	DTP3 TFA
PL03822	Indirubin-3′-oxime	667463-82-3
PC11835	IQ 3	312538-03-7
PL01041	IQ-1S free acid	23146-22-7
PL02767	J30-8	2366255-71-0
PC11791	JIP-1 (153-163)	438567-88-5
PC11755	JNK-IN-7	1408064-71-0
PL05944	JTP10-△-R9 TFA
PL05943	JTP10-△-TATi TFA