5-Lipoxygenase

Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

5-Lipoxygenase 相关产品（16）

货号	产品名	Cas	产品描述
PC12727	1-Naphthyl 3,5-dinitrobenzoate	93261-39-3	5-脂氧合酶和微粒体前列腺素E合酶-1的双重抑制剂，IC50: 1 and 3.6 μM for 5-lipoxygenase and microsomal prostaglandin E synthase-1, respectively，1-Naphthyl 3,5-dinitrobenzoate is a dual 5-lipoxygenase and microsomal prostaglandin E synthase-1 inhibitor.
PC12699	11-keto-β-Boswellic Acid	17019-92-0	通过5-脂氧合酶合成白三烯的抑制剂，11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) 是一种五环三萜酸，来自俗称印度乳香 (Indian Frankincense) 的乳香树 (Boswellia serrate) 树皮的油树脂。
PC11577	2-TEDC	132465-10-2	5-，12-和15-脂氧合酶抑制剂
PC12698	3-acetyl-11-keto-β-Boswellic Acid	67416-61-9	5-脂氧合酶抑制剂，Acetyl-11-Keto-_beta_-Boswellic Acid (AKBA)是一种从乳香中提取出的活性化合物，被发现是新颖的Nrf2的活化剂。
PC11564	BAY-X 1005	128253-31-6	FLAP的强效抑制剂,Veliflapon (BAY X 1005; DG-031) 是一种具有口服活性的白三烯 B4 和 C4 合成的抑制剂。Veliflapon 是一种选择性的体外 5-脂氧合酶衍生代谢物形成的抑制剂，对花生四烯酸代谢的其他途径没有影响。
PC12743	BW 755C	66000-40-6	5-脂氧合酶（5-LO）和环加氧酶（COX）通路的双重抑制剂，IC50: 0.75 μM, 0.65 μg/ml, and 1.2 μg/ml for 5-LO, COX-1, and COX-2, respectively，BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.
PC11579	BW-B 70C	134470-38-5	5-脂氧合酶抑制剂，BW-B 70C是一种强效的和选择性的5-脂氧合酶抑制剂.BW-B 70C在体内具有较高的效力和较长的持续时间,被认为是潜在的抗哮喘药物
PC12755	Ebselen	60940-34-3	环氧合酶和脂氧合酶抑制剂，Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。
PC12738	HZ52	1077626-51-7	5-脂氧合酶抑制剂，2-(4-(biphenyl-4-ylamino)-6-chloropyrimidin-2- ylthio)octanoic acid (HZ52) is an inhibitor for 5-Lipoxygenase (5-LO) [1]. 5-Lipoxygenase (5-LO), the key enzyme involved in the biosynthesis of pro-inflammatory leukotrienes (LTs), is a potential t
PC11524	Malotilate	59937-28-9	刺激肝细胞再生,Malotilate可作用于肝细胞，促进其RNA合成，激活核糖体，提高蛋白质合成能力，从而激活肝功能并抑制肝纤维化，还能抑制肝内4-羟基脯氨酸量的增加。
PC11580	MK 886	118414-82-7	FLAP和PPARα抑制剂，抑制白三烯生物合成，MK886是<5>脂氧合酶活化蛋白抑制剂和白三烯生物合成抑制剂 (IC50=2.5 nM)。
PC11585	PD 146176	4079-26-9	15-脂氧合酶（15-LOX）抑制剂，PD146176 (NSC168807) 是 15-脂氧合酶 (15-LO) 抑制剂，抑制兔网织红细胞中 15-LO 的 Ki 值为 197 nM。PD146176 (NS168807) 在减少动脉粥样硬化方面有显著效果。
PC12761	Piriprost (potassium salt)	88851-62-1	5-脂氧合酶抑制剂，Piriprost (U 60257) is a leukotriene synthesis inhibitor [1].
PC11542	Zileuton	111406-87-2	5-脂氧合酶（5-LOX）抑制剂,Zileuton是有效，选择性的5-脂氧合酶抑制剂，具有抗哮喘特性。
PC11550	Zileuton sodium	118569-21-4	5-脂氧合酶和白三烯抑制剂,Zileuton sodium 是一种有效的，选择性的 5-lipoxygenase 抑制剂，具有抗炎的作用。
PC11596	β-acetyl-Boswellic Acid	5968-70-7	5-脂氧合酶（5-LO）的非还原抑制剂，3-Acetyl-beta-boswellic acid 是从乳香锯缘胶树脂中分离得到的乳香酸。