TSH Receptor

Thyrotropin receptor; Thyroid-stimulating hormone Receptor

The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of family A G protein-coupled receptors. The TSH receptor (TSHR) undergoes complex post –translational modifications including intramolecular cleavage and receptor multimerization. TSHR and its endogenous ligand thyrotropin (TSH) are of essential importance for growth and function of the thyroid gland and proper function of the TSH/TSHR system is pivotal for production and release of thyroid hormones.

The TSHR activates different G-protein subtypes and signaling pathways, whereby Gs- and Gq-induced signaling are probably of highest importance. TSH and its receptor are required for thyroid hormone synthesis and release in the thyroid gland. Dysfunctions of the TSHR are the underlying cause of various gain- or loss-of-function phenotypes associated with thyroid malfunction. It has been suggested that the TSHR is involved in the development and mechanisms of ophthalmopathy. TSHR is also a major autoantigen for autoimmune diseases of the thyroid gland. In addition, TSHR has been proposed to be a potent target against thyroid cancer with several experimental compounds under development.

TSH Receptor 相关产品（9）

货号	产品名	Cas
PL12486	D3-βArr	662164-09-2
PL11824	ML-109	1186649-91-1
PC10786	ML224	1338824-21-7
PL12484	NCGC00229600	1338824-20-6
PL12488	Org41841	301847-37-0
PL12489	Teprotumumab	1036734-93-6
PL12487	TSHR antagonist S37a	2143452-20-2
PL12490	TSHR antagonist S37b	2143452-22-4
PL12485	VA-K-14 hydrochloride	1171341-19-7