异柠檬酸脱氢酶(IDH)

Isocitrate dehydrogenase (IDH), one of the key enzymes in the citric acid cycle, catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG) generating carbon dioxide and NADPH/NADH. IDHs belong to a large ancient family of enzymes that play central roles in energy metabolism, amino acid biosynthesis and vitamin production.

IDH protein family consists of three self-regulating enzymes (IDH1, IDH2, and IDH3). IDH1 and IDH2 are both nicotinamide adenine dinucleotide phosphate (NADP)-dependent enzymes that catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG), while producing NADPH either in peroxisomes and the cytosol (IDH1) or in mitochondria (IDH2). IDH3 catalyzes the same reaction in the mitochondria, but in a NAD-dependent fashion. Mutations in IDH1 and IDH2 have been demonstrated in a variety of malignancies. IDH inhibitors have engendered hope in IDH1/2 mutant myeloid malignancies.

异柠檬酸脱氢酶(IDH) 相关产品（19）

货号	产品名	Cas
PL14796	(R,R)-GSK321	1816272-19-1
PL14803	(R,S)-Ivosidenib	2070009-31-1
PL14799	(S,R)-GSK321	1816272-18-0
PL14795	(S,S)-GSK321	1816272-20-4
PL14808	AGI-5198	1355326-35-0
PL14810	AGI-6780	1432660-47-3
PL14805	BAY-1436032	1803274-65-8
PL14802	DS-1001b	1898207-64-1
PL14811	Enasidenib	1446502-11-9
PL14804	Enasidenib mesylate	1650550-25-6
PL14807	GSK321	1816331-63-1
PL14806	IDH-305	1628805-46-8
PL14797	IDH1 Inhibitor 1	2234285-81-3
PL14800	IDH889	1429179-07-6
PL14801	Mutant IDH1 inhibitor	1429180-08-4
PL14798	Mutant IDH1-IN-2	1429176-69-1
PL14794	Mutant IDH1-IN-4	1416270-18-2
PL14809	Vorasidenib	1644545-52-7
PC22003	甘草酸二铵.	79165-06-3