MAGL

Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the hydrolysis of monoglycerides into glycerol and fatty acids. MAGL links the endocannabinoid and eicosanoid systems together by degradation of the abundant endocannabinoid 2-arachidaoylglycerol into arachidonic acid, the precursor of prostaglandins and other inflammatory mediators.

MAGL plays a critical role in lipid signalling: i) it is the major enzyme that controls the levels of 2-AG, an important lipid with various neuroprotective effects; ii) inactivation of MAGL induces an elevation in brain levels of 2-AG and a reduction of AA, a key precursor of pro-inflammatory prostaglandins, resulting in the reduction of neuroinflammation; iii) MAGL regulates the levels of free fatty acids (FFAs) in aggressive cancer cells, and this MAGL-promoted fatty acid network drives a number of pro-tumorigenic signalling pathways. MAGL is emerging as a promising drug target for various diseases.

MAGL 相关产品（14）

货号	产品名	Cas
PL06914	AA38-3	65815-76-1
PL06905	ABD957
PL06902	Arachidonoyl Serinol	183718-70-9
PL06909	DO-264	2301866-59-9
PL06910	Elcubragistat	1446817-84-0
PL06912	JNJ-42226314	1252765-13-1
PL06906	JW 642	1416133-89-5
PL06913	JZL 184	1101854-58-3
PL06908	JZP-430	1672691-74-5
PL06911	KT185	1472640-86-0
PL06907	MAGL-IN-1	2324160-91-8
PL06904	MAGL-IN-4	2135785-20-3
PL06903	MGL-IN-1	1881244-28-5
PC15301	MJN110	1438416-21-7