IDO

Indoleamine 2, 3-dioxygenase (IDO) is an inflammatory cytokine-inducible rate-limiting enzyme of the tryptophan (Trp) catabolism, which is involved in the inhibition of intracellular pathogen replication as well as in immunomodulation. To date, three types of tryptophan-metabolizing enzymes have been identified: IDO1, IDO2 and tryptophan 2,3-dioxygenase 2.

IDO is an intracellular enzyme that is constitutively expressed in several human and mouse cells. Being present in innate immune cells, such as Mos and dendritic cells (DCs), IDO catalyzes the initial rate-limiting step of tryptophan (Trp) catabolism, thus leading to the production of immunoregulatory catabolites (collectively known as kynurenines).

The IDO gene promoter contains multiple sequence elements that confer responsiveness to proinflammatory mediators, thereby demonstrating the strong correlation between inflammation and induced IDO expression.

IDO 相关产品（32）

货号	产品名	Cas
PL01933	(Rac)-IDO1-IN-5	2166616-74-4
PL03384	(Rac)-Indoximod	26988-72-7
PL01934	(S)-IDO1-IN-5	2166616-76-6
PL05692	(S)-Indoximod-d3	1801851-87-5
PL04836	BMS-978587	1629125-65-0
PL03818	BMS-986242	1923844-48-7
PL04268	DP00477	169120-56-3
PL04502	Epacadostat	1204669-58-8
PL01115	GNF-PF-3777	77603-42-0
PL02006	IACS-8968	2144425-14-7
PL02007	IACS-8968 R-enantiomer	2239305-67-8
PL02008	IACS-8968 S-enantiomer	2239305-70-3
PC12454	IDO inhibitor 1	1204669-37-3
PC12702	IDO-IN-1	914638-30-5
PL02242	IDO-IN-12	1888341-29-4
PL04685	IDO-IN-3	2070018-30-1
PL04837	IDO-IN-5	1402837-79-9
PL04838	IDO-IN-6	1402837-76-6
PL03879	IDO-IN-7	1402836-58-1
PL04839	IDO-IN-8	1402837-77-7