Pyk2

Proline-rich tyrosine kinase 2 (Pyk2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and considered a viable drug target for osteoporosis treatment.

Pyk2 and focal adhesion kinase (FAK) comprise the focal adhesion kinase subfamily of non-receptor tyrosine kinases. PYK2 and FAK are large multidomain proteins containing an N-terminal FERM domain, a central catalytic domain, and a C-terminal segment containing dual proline rich (PR) subdomains and a focal adhesion targeting (FAT) region.

Pyk2, a non-receptor tyrosine kinase of the FAK family, is up-regulated in more than 60% of the tumors of hepatocellular carcinoma (HCC) patients.

Pyk2 相关产品（4）

货号	产品名	Cas	产品描述
PC16085	PF-431396	717906-29-1	Pyk2和FAK抑制剂，PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treati
PL10746	PF-4618433	1166393-85-6	PF-4618433 是一种有效的、选择性的 PYK2 抑制剂，IC50 值为 637 nM。PF-4618433 可能适用于研究骨质疏松症，颅面和阑尾骨骼缺损以及靶向骨再生。
PC16070	PF-562271	717907-75-0	ATP竞争性的FAK抑制剂，PF-562271 是有效，可逆，ATP竞争性的 FAK 和 Pyk2 激酶抑制剂，IC50 分别为 1.5 和 13 nM。
PC16073	PF-562271 HCl	939791-41-0	FAK/Pyk2抑制剂，PF-562271 是一种强效的、ATP竞争性的和可逆的局部粘着斑激酶(FAK)和富含脯氨酸的酪氨酸激酶2 (Pyk2)抑制剂，半数最大抑制浓度（IC50）分别为1.5 nmol/L和14 nmol/L。