IKK

IKK is a complex composed of three subunits: IKKα, IKKβ, and IKKγ (also called NEMO). The complex is the signal integration hub for NF-κB activation. It integrates signals from all NF-κB activating stimuli to catalyze the phosphorylation of various IκB and NF-κB proteins, as well as of other substrates. The human IKK family has four members, the IKKs IKK-alpha and IKK-beta, and the IKK-related kinases TBK1 and IKK-epsilon.

Two members, IKKα and IKKβ, the so-called canonical members, phosphoryate IκBα, leading to activation of the transcription factor NF-κB, which controls the expression of many immune and inflammatory genes. The IKK-related proteins TBK-1 and IKK-epsilon have a different substrate--IRF3--which regulates a different set of genes, the products of which include Type I interferons. IKKs are a therapeutic target due to their crucial roles in various biological processes, including the immune response, the stress response, and tumor development.

IKK 相关产品（22）

货号	产品名	Cas
PL01626	(Rac)-PF-184 hydrate
PL03340	BAY-985	2409479-29-2
PL06535	BAY32-5915	1571-30-8
PL03110	BI605906	960293-88-3
PL04881	Ertiprotafib	251303-04-5
PL01843	GS143	916232-21-8
PL01973	GSK8612	2361659-62-1
PL02568	HOIPIN-1
PL03460	HPN-01	928655-63-4
PL03641	IKK 16	873225-46-8
PL03769	IKK-IN-1	406211-06-1
PL01526	IMD-0560	439144-66-8
PL02225	INH14	200134-22-1
PL05414	LY2409881	946518-61-2
PL05415	LY2409881 trihydrochloride	946518-60-1
PL05593	Malachite green oxalate	2437-29-8
PL04440	MLN120B dihydrochloride	1782573-78-7
PL03956	PHA 408	503555-55-3
PL03560	Resveratrol analog 1	861446-16-4
PC54261	SC-514	354812-17-2