CX3C chemokine receptor1 (CX3CR1), also known as the fractalkine receptor or GPR13, is the specific receptor to the CX3CL1. As the name suggests, CX3CR1 binds the chemokine CX3CL1 (also called fractalkine (in humans) or neurotactin (in mouse) ). CX3CL1 is a member of the CX3C family and that has been detected on activated endothelial cells, smooth muscle cells (SMCs), macrophages and platelets. CX3CL1 is the only neuronal chemokine in the body with pro-inflammatory, anti-inflammatory and neuroprotective effects, and is involved in the development of numerous inflammatory pathologies including atherosclerosis, rheumatoid arthritis, or graft rejection.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PL03740 | AZD8797 | 911715-90-7 | AZD8797 (KAND567) 是非竞争性、可口服的人 CX3CR1 变构拮抗剂，拮抗 CX3CR1 和 CXCR2，Ki 分别为 3.9 和 2800 nM。 |
| PL01615 | E6130 | 1427058-33-0 | E6130 是一种具有口服活性的，高度选择性的 CX3CR1 调节剂，有研究炎症性肠病的潜力。 |
| PL02629 | JMS-17-2 | 1380392-05-1 | JMS-17-2 是一种有效的选择性 CX3CR1 拮抗剂，IC50 为 0.32 nM。JMS-17-2 降低乳腺癌细胞的转移和定植。 |
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