CTLA-4

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily. CTLA-4 is expressed primarily by T cells. The ligands of CTLA-4, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4. The interactions of the ligands with CTLA-4 serve to inhibit T cell responses. Because of its dampening effect, CTLA-4 is a crucial regulator of T-cell homeostasis and self-tolerance. The mechanisms by which CTLA-4 exerts its inhibitory function can be categorized as either cell-intrinsic (affects the CTLA-4 expressing T-cell) or cell-extrinsic (affects secondary cells). CTLA-4 is well recognized as a key immune checkpoint and has gained significant momentum as a therapeutic target in the field of autoimmunity and cancer.

CTLA-4 相关产品（3）

货号	产品名	Cas	产品描述
PL01700	Abatacept	332348-12-6	Abatacept (CTLA4lg) 是一种可溶性融合蛋白，由人 CTLA4 的胞外结构域和人 IgG1 Fc 部分的片段 (铰链，CH2 和 3 结构域) 组成。Abatacept 是选择性 T 细胞共刺激调节剂，也是一种用于自身免疫性疾病的蛋白药物。
PL05997	Ipilimumab	477202-00-9	Ipilimumab 是一种全人类单克隆抗体 IgG1κ，可阻断 T 细胞上的抑制性受体细胞毒性 T 淋巴细胞抗原4（CTLA-4）。Ipilimumab 可用于不可切除或转移性黑色素瘤（MM）研究。
PL06045	Vudalimab	2329669-72-7	Vudalimab 是一种有效的 PD-1 和 CTLA-4 双重抑制剂，是一种完全人源化的双特异性单克隆抗体。Vudalimab 靶向免疫检查点受体 PD-1 和 CTLA-4，促进肿瘤选择性 T 细胞激活。