VDAC

VDAC (voltage-dependent anion selective channel) proteins, also known as mitochondrial porins, are the most abundant proteins of the outer mitochondrial membrane (OMM) where they play a vital role in various cellular processes, in the regulation of metabolism, and in survival pathways. They mediate the ions (such as Ca²⁺) and metabolites (such as succinate or ATP, tRNA or DNA) exchange between mitochondria and the rest of the cell, ensuring good functionality of mitochondrial complexes and energy production.

In higher eukaryotes, there are three VDAC isoforms (VDAC1, VDAC2, VDAC3) encoded by separate genes located on different chromosomes. VDAC has the potential for the research of cancer and Alzheimer's disease.

VDAC 相关产品（3）

货号	产品名	Cas	产品描述
PL12566	Erastin	571203-78-6	Erastin 是一种铁死亡 (ferroptosis) 诱导剂。Erastin 可选择性杀伤细胞，靶向表达 RAS 致癌突变体的细胞。Erastin 的铁死亡诱导机制与 ROS 和铁依赖性信号传导有关。Erastin 能够抑制电压依赖性阴离子通道 (VDAC2/VDAC3)，加速氧化，导致内源活性氧积累。Erastin 还破坏线粒体通透性过渡孔 (mPTP)，表现出抗肿瘤活性。
PL09490	NSC 15364	4550-72-5	NSC 15364 是一种 VDAC1 寡聚化和细胞凋亡 (apoptosis) 抑制剂。
PL12565	WEHI-9625	2595314-46-6	WEHI-9625 是一种首创的，三环砜小分子凋亡抑制剂，EC50 值为 69 nM。WEHI-9625 与 VDAC2 结合可促进其抑制小鼠 BAK 诱导的细胞凋亡的能力，但对人 BAK 和与凋亡效应密切相关的 BAX 因子均完全无效。