PI3K

PI3K (Phosphoinositide 3-kinase), via phosphorylation of the inositol lipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂), forms the second messenger molecule phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P₃) which recruits and activates pleckstrin homology domain containing proteins, leading to downstream signalling events crucial for proliferation, survival and migration. Class I PI3K enzymes consist of four distinct catalytic isoforms, PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ.

There are three major classes of PI3K enzymes, being class IA widely associated to cancer. Class IA PI3K are heterodimeric lipid kinases composed of a catalytic subunit (p110α, p110β, or p110δ; encoded by PIK3CA, PIK3CB, and PIK3CD genes, respectively) and a regulatory subunit (p85).

The PI3K pathway plays an important role in many biological processes, including cell cycle progression, cell growth, survival, actin rearrangement and migration, and intracellular vesicular transport.

PI3K 相关产品（134）

货号	产品名	Cas
PL09769	(Rac)-AZD 6482	663620-70-0
PL09782	(S)-PI3Kα-IN-4	2322293-84-3
PC54321	1-Deoxynojirimycin (hydrochloride)	73285-50-4
PC15456	1173204-81-3	1173204-81-3
PC15492	740 Y-P	1236188-16-1
PC15495	Acalisib (GS-9820)	870281-34-8
PL08763	ACT001	1582289-91-5
PL09789	AMG 511	1253573-53-3
PL09798	AMG319	1608125-21-8
PL09608	AQX-016A	849669-54-1
PC15518	AS-041164	6318-41-8
PC15476	AS-252424	900515-16-4
PC15477	AS-604850	648449-76-7
PC15447	AS-605240	648450-29-7
PL09281	Autophinib	1644443-47-9
PL09829	AZ2	2231760-33-9
PL09824	AZD-7648	2230820-11-6
PL09791	AZD3458	2132961-46-5
PL09758	AZD8154	2215022-45-8
PL09805	AZD8186	1627494-13-6