SPHK

Sphingosine kinase (SphK1 and SphK2) is a lipid enzyme that catalyses the phosphorylation of sphingosine to form sphingosine 1-phosphate (S1P). Two isoforms of SphK are found in mammalian organisms, SphK1 and SphK2. SphK1 is found primarily in the cytoplasm and the plasma membrane of erythrocyte, endothelial and mast cells. SphK2 is larger and localized to the endoplasmic reticulum, nucleus, and mitochondria.

S1P binds to five different plasma membrane sphingosine 1-phosphate receptors (S1P_1-5) and can regulate intracellular target proteins. S1P has a wide range of biological functions including promotion of cellular proliferation and survival, immune cell trafficking, stimulation of angiogenesis, and regulation of vascular integrity. Accumulation of S1P has been linked to the development/progression of cancer and various other diseases including, but not limited to, asthma, inflammatory bowel disease, rheumatoid arthritis, and diabetic nephropathy. Thus, the biosynthetic route to S1P is a logical target for drug discovery. SphK1 and SphK2 isozymes are also recognized therapeutic targets.

SPHK 相关产品（12）

货号	产品名	Cas
PC14923	K145	1309444-75-4
PC54520	K145 (hydrochloride)	1449240-68-9
PL11422	K6PC-5	756875-51-1
PL11417	MHP	1104874-94-3
PL11416	MP-A08	219832-49-2
PL10815	Peretinoin	81485-25-8
PC14791	PF-543 Citrate	1415562-83-2
PL11420	SK1-IN-1	1218816-71-7
PL11418	SK1-I hydrochloride	2366222-05-9
PL09774	SKI V	24418-86-8
PL11419	SKI-178	1259484-97-3
PL11421	SKI-I	306301-68-8