SK1-I hydrochloride|2366222-05-9|(BML-258 hydrochloride)-陌孚医药/Medlife

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SK1-I hydrochloride (Synonyms: BML-258 hydrochloride)

目录号: PL11418 纯度: ≥99%

CAS No. :2366222-05-9

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PL11418-100mg	100mg	¥40181.00	请登录
PL11418-200mg	200mg	询价	询价
PL11418-500mg	500mg	询价	询价

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中文名称	SK1-I hydrochloride
英文名称	SK1-I hydrochloride
英文别名	SK1-I hydrochloride;SK1-I hydrochloride
Cas No.	2366222-05-9
分子式	C₁₇H₂₇NO₂^.ClH
分子量	313.87
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	SK1-I hydrochloride (BML-258 hydrochloride) 是鞘氨醇的类似物，是同功酶特异性 SPHK1 竞争抑制剂，K_i 值为 10 µM。SK1-I hydrochloride 对 SPHK2，PKCα，PKCδ，PKA，AKT1，ERK1，EGFR，CDK2，IKKβ 或 CamK2β 无活性。SK1-I hydrochloride 增强自噬并具有抗肿瘤活性。
生物活性	SK1-I hydrochloride (BML-258 hydrochloride), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a K i value of 10 μM. SK1-I hydrochloride shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I hydrochloride enhances autophagy and has antitumor activity.
性状	Liquid
IC50 & Target[1][2]	SphK1
体外研究(In Vitro)	SK1-I hydrochloride (0-10 μM; 24 hours) attenuates cancer cell growth and survival in a TP53-dependent manner in HCT116 cells and HCT116 cells bearing TP53 null cancer. SK1-I hydrochloride (0-20 μM; 12 hours) induces more CASP3 cleavage in HCT116 cells, compared to HCT116 cells lacking TP53, leading to a hallmark of apoptosis. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	Pre-treatment with SK1-I hydrochloride (BML-258 hydrochloride; intraperitoneal (i.p.) injection; once; 24 hours prior to baseline mean arterial blood pressure (MAP) measurement; 75 mg/kg) before anandamide (i.v. injection; two doses; 1 and 10?mg/kg) significantly decreases the hypotensive response. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Melissa R Pitman, et al. Inhibitors of the sphingosine kinase pathway as potential therapeutics. Curr Cancer Drug Targets. 2010 Jun;10(4):354-67. [2]. Santiago Lima, et al. TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition. Autophagy. 2018;14(6):942-957.

溶解度数据	In Vitro: DMSO : 250 mg/mL (796.53 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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