Imidazoline Receptors

Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.

Imidazoline Receptors 相关产品（8）

货号	产品名	Cas	产品描述
PC15141	2-BFI hydrochloride	89196-95-2	I2配体，A highly potent, selective imidazoline I2 receptor agonist with Ki of 9.8 nM, enhances supraspinal morphine analgesia in mice..
PC15171	AGN 192403 hydrochloride	1021868-90-5	I1咪唑啉受体的配体
PC15156	BU 224 hydrochloride	205437-64-5	I2咪唑啉受体拮抗剂
PC15172	BU 226 hydrochloride	1186195-56-1	I2咪唑啉位点配体
PC15036	BU 239 hydrochloride	1217041-98-9	咪唑啉受体的选择性拮抗剂
PC14811	Moxonidine	75438-57-2	I1R/α2AR激动剂，Moxonidine(BDF5895)是咪唑啉1型受体（I1-R）选择性激动剂，为降压剂。
PC15031	Rilmenidine Phosphate	85409-38-7	靶向咪唑啉受体的抗高血压药.Rilmenidine phosphate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体 (I1 imidazoline receptor) 激动剂。Rilmenidine phosphate 可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+ 反向转运而在肾脏中发挥作用。
PC15039	RS 45041-190 hydrochloride	204274-74-8	高选择性I2咪唑啉受体的配体