SRC

Src family kinase (SFK) is a family of non-receptor tyrosine kinases including nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. In immune cells, Src-family kinases (SFKs) have been implicated as critical regulators of a large number of intracellular signaling pathways. Src-family kinases (SFKs) occupy a proximal position in numerous signaling transduction cascades including those emanating from the T and B cell antigen receptors, Fc receptors, growth factor receptors, cytokine receptors, and integrins. In addition to these positive regulatory roles, Src-family kinases (SFKs) can also function as negative regulators of cellular signaling by phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, resulting in recruitment and activation of inhibitory molecules such as the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1).

SRC 相关产品（59）

货号	产品名	Cas
PL11427	1-Naphthyl PP1 hydrochloride	956025-47-1
PC16089	1-NM-PP1	221244-14-0
PC16090	A 419259 trihydrochloride	1435934-25-0
PL11447	A-770041	869748-10-7
PL10783	AD57	1093380-42-7
PL10782	AD80	1384071-99-1
PL11431	AZM475271	476159-98-5
PL11443	Bafetinib	859212-16-1
PL11438	Bosutinib hydrate	918639-08-4
PL11439	Bosutinib-d8
PL11425	Caffeic acid-pYEEIE TFA
PL11426	CGP77675	234772-64-6
PL11433	CH6953755	2055918-71-1
PC16150	Damnacanthal	477-84-9
PC16026	Dasatinib hydrochloride	854001-07-3
PL11437	Dasatinib-d8	1132093-70-9
PL11429	DGY-06-116	2556836-50-9
PL11434	eCF506	1914078-41-3
PL11436	Elzovantinib	2271119-26-5
PL09031	ENMD-2076	934353-76-1