Retinoid X Receptors

The nuclear retinoic acid receptors (RARs) are transcriptional transregulators, which control the expression of specific gene subsets subsequently to ligand binding and to strictly controlled phosphorylation processes. RARs consist of three subtypes, α (NR1B1), β (NR1B2) and γ (NR1B3), encoded by separate genes. RARs function as ligand-dependent transcriptional regulators, heterodimerized with retinoid X receptors (RXRs), which also consist of three types, α NR2B1, β (NR2B2) and γ (NR2B3). RARs play critical roles in a variety of biological processes, including development, reproduction, immunity, organogenesis and homeostasis, as assessed by vitamin A-deficiency (VAD), pharmacological and genetic studies conducted in the mouse.

Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function.

Retinoid X Receptors 相关产品（11）

货号	产品名	Cas	产品描述
PC14835	Bexarotene	153559-49-0	类视黄醇受体激动剂，Bexarotene是用于治疗皮肤T细胞淋巴瘤的选择性类视黄醇X受体 (retinoid X receptors (RXR)) 激动剂。
PC15221	CD 3254	196961-43-0	有效的RXRα选择性激动剂，CD3254 是一种有效的选择性类视黄醇 X 受体 (RXR) 激动剂。
PC15137	Etretinate.	54350-48-0	类视黄醇受体激动剂，Etretinate(Ro 10-9359)是一用于治疗银屑病的药物，临床上已被acitretin取代使用。
PC15077	Fluorobexarotene	1190848-23-7	RXR激动剂，Fluorobexarotene (compound 20) 是一种有效的类视黄醇 X 受体 (RXR) 激动剂。Fluorobexarotene 对 RXRα 受体的 Ki 值为 12 nM，EC50 值为 43 nM。Fluorobexarotene 具有明显的 RXR 结合亲和力，比 Bexarotene 高75%。
PC15071	HX 531	188844-34-0	RXR拮抗剂，HX 531 is an antagonist of retinoid X receptors.
PC15072	HX 630	188844-52-2	RXR激动剂
PC15246	LG 100754	180713-37-5	新型RXR：PPARγ激动剂，LG100754 (UVI 2112) 是一种 RXR 二聚体的调节剂。LG100754 作为同源二聚体 RXR:RXR 的拮抗剂，但作为异源二聚体 RXR: PPARα 和 RXR: PPARγ 的激动剂。LG100754 是一种通过 RXR 起作用的胰岛素增敏剂。
PC15230	LG 101506	331248-11-4	RXR调节剂
PC15273	PA 452	457657-34-0	RXR拮抗剂，PA452 是一种视黄酸 X 受体 (RXR) 拮抗剂，抑制视黄酸 (RA) 对 Th1/Th2 发育的影响。
PC15228	SR 11237	146670-40-8	泛类视黄醇X受体（RXR）激动剂，A selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity.
PC15222	UVI 3003	847239-17-2	RXR拮抗剂，UVI 3003 是一种高度选择性的 retinoid X receptor (RXR) 抑制剂，在 Cos7 细胞中，抑制非洲爪蟾蜍和人 RXRα 的活性，IC50 值分别为 0.22 和 0.24 μM。