IGF-1R (Insulin-like growth factor 1 receptor), a receptor tyrosine kinase, is activated upon binding to the ligands IGF-1 or IGF-2 leading to cell growth, survival and migration of both normal and cancerous cells.
IGF-1R can initiate the activation of the PI3K/AKT/mTOR signaling and Ras/Raf/MEK/MAPK pathways resulting in the activation of multiple transcription factors such as ELK-1, CREB and AP-1 to modulate cell proliferation, survival, differentiation, motility, invasion and angiogenesis. IGF-1R overexpression or increased IGF-1R kinase activity is associated with a broad range of human cancers and therefore the IGF-1R is widely considered as a very promising target for cancer treatment.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PC16005 | BMS-536924 | 468740-43-4 | IR/IGF-1R抑制剂,BMS-536924是ATP竞争性IGF-1R/IR抑制剂， IC50分别为100 nM/73 nM。 |
| PC16166 | NT157 | 1384426-12-3 | IRS-1/2抑制剂，抑制IGF-1R和STAT3信号通路,NT157是一种选择性的IRS-1/2抑制剂IC50 为 0.3 到0.8 μM。 |
| PC16003 | PQ 401 | 196868-63-0 | IGF1R抑制剂,PQ401是IGF1R阻断剂，能抑制IGF1R自磷酸化，IC50 < 1 uM。 |
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