Monoamine transporter

Monoamine transporters (MATs) belong to the solute carrier 6 (SLC6) family of human transporters, which, in turn, is a subfamily of the broader neurotransmitter:sodium symporters (NSSs) that comprise transporters from prokaryotic to human. MATs comprise three main members-the dopamine (DA) transporter (DAT), serotonin transporter (SERT) and norepinephrine transporter (NET). MATs regulate neurotransmission via the reuptake of dopamine, serotonin and norepinephrine from extra-neuronal regions and thus maintain neurotransmitter homeostasis.

MATs are transmembrane proteins located in plasma membranes of monoaminergic neurons. These proteins use ion (Na⁺, Cl⁻) gradients as energy sources to move monoamines into or out of neurons. In the membrane of intracellular synaptic vesicles is the vesicular monoamine transporters 1 and 2 (VMAT1 and VMAT2), which use a proton gradient as the energy source to sequester cytosolic monoamines into the vesicles and then release the monoamines into synaptic cleft by exocytosis. Dysregulation of MATs has been linked to depression, anxiety disorder, attention-deficit-hyperactivity disorder, obsessive-compulsive disorder, substance-use disorders, epilepsy, Parkinson’s disease and autism-spectrum disorder. Thus, MATs serve as pharmacological targets for several neuropsychiatric and neurodegenerative disorders.

Monoamine transporter 相关产品（12）

货号	产品名	Cas
PL07513	(+)-Tetrabenazine	1026016-83-0
PL07512	FFN200 dihydrochloride	2080306-27-8
PL07510	hENT4-IN-1	949467-71-4
PC54512	Lazabemide	103878-84-8
PL07515	NBI-98782	85081-18-1
PL07516	Nisoxetine	53179-07-0
PL07517	Radafaxine hydrochloride	106083-71-0
PC11915	Reserpine hydrochloride	16994-56-2
PL07511	Reserpine-d9	84759-11-5
PL07514	Tetrabenazine Racemate	718635-93-9
PL07519	Tetrabenazine-d6	1392826-25-3
PL07518	Valbenazine	1025504-45-3