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Transketolase 是磷酸戊糖途径 (PPP) 非氧化分支中的关键限速酶。Transketolase 对于能量转导和产生用于核酸合成的核糖至关重要。Transketolase 可以将核酮糖 5-磷酸转化回葡萄糖 6-磷酸以产生更多的 NADPH，并且该反应是硫胺素依赖性的。Transketolase 有三种异构体：TKT、TKTL1和TKTL2。TKT 在所有研究的生物体中均有表达，并在多种癌症类型中上调。
Transketolase is a key rate-limiting enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP). Transketolase is critical for energy transduction and for generating ribose for nucleic acid synthesis. Transketolase can convert ribulose 5-phosphate back into glucose 6-phosphate to generate more NADPH, and the reaction is thiamine-dependent. Transketolase has three isomer: TKT, TKTL1 and TKTL2. TKT is expressed in all investigated organisms, and is up-regulated in multiple cancer types.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PL12403 | N3PT | 13860-66-7 | |
| PL11743 | Oxythiamine diphosphate ammonium |
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