Aminopeptidase(氨肽酶)

Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates. Regarding catalytic mechanism, most of the aminopeptidases are metallo-enzymes but cysteine and serine peptidases are also included in this group. Aminopeptidases are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Several aminopeptidases perform essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes and are inhibited by the transition-state analog bestatin. Some are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits.

Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN) and insulin-regulated aminopeptidase (IRAP). These enzyme activities generate active or inactive angiotensin peptides that alter the ratios between their bioactive forms, regulating several important processes such as the regulation of cardiovascular functions, body water regulation, normal memory consolidation and retrieval, but also cell growth, differentiation and apoptosis or the inflammatory response.

Aminopeptidase(氨肽酶) 相关产品（15）

货号	产品名	Cas	产品描述
PL13314	Acebilustat	943764-99-6	Acebilustat (CTX-4430) 是一种可口服的白三烯 A4 水解酶抑制剂，用于炎症研究。
PL13317	Aminopeptidase-IN-1	374102-08-6	Aminopeptidase-IN-1 (compound 16o) 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂，Ki 为 7.7 μM。Aminopeptidase-IN-1 可用于研究认知和记忆障碍。
PC15767	Arphamenine B (hemisulfate)	144110-38-3	氨肽酶B抑制剂，Arphamenine B is a specific inhibitor of aminopeptidase B first isolated from bacteria [1]. Aminopeptidase B (Ap-B) is a Zn2+-dependent exopeptidase which selectively removes Arg and/or Lys residues from the N terminus of several peptide substrate
PC15611	Bestatin	58970-76-6	氨肽酶抑制剂，Bestatin是一种天然，广谱，竞争性的氨肽酶抑制剂。
PC15718	Bestatin hydrochloride	65391-42-6	氨肽酶N（APN/CD13）和氨肽酶B抑制剂，Bestatin hydrochloride 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，常用于癌症治疗。
PL13315	DG051	929915-58-2	DG051 是一种有效的白三烯 A4 水解酶 (leukotriene A4 hydrolase) 抑制剂，IC50 为 47 nM。
PL13318	Firibastat	648927-86-0	Firibastat (QGC001) 是一种口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A (APA) 抑制剂 (Ki=200 nM)，选择性和特异性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III，并降低血压。
PC15680	Fumagillin	23110-15-8	抗生素和抗血管生成剂，Fumagillin(NSC9168)由烟曲霉菌中提取，有抗抗阿米巴活性。
PL13316	HFI-142	332164-34-8	HFI-142 是胰岛素调节性氨基肽酶 (IRAP) 抑制剂，Ki 值为 2.01 μM。
PC15762	L-Leucine 4-methoxy-β-naphthylamide (hydrochloride)	4467-68-9	氨基肽酶M和亮氨酸氨基肽酶的底物，L-Leucine 4-methoxy-β-naphthylamide is a substrate for aminopeptidase M and leucine aminopeptidase.
PL13321	LTA4H-IN-1	1799681-85-8	LTA4H-IN-1 是一种有效的白三烯 A4 水解酶 LTA4H 抑制剂，IC50 值为 2 nM。LTA4H-IN-1 可用于研究炎症和自身免疫性疾病。详细信息请参考专利文献 WO2015092740A1 中的化合物 29。
PL13320	NGR peptide Trifluoroacetate		NGR peptide Trifluoroacetate 是含有 Asn-Gly-Arg (NGR) 基序的肽。NGR peptide Trifluoroacetate 与 APN/CD13 结合。NGR peptide Trifluoroacetate 直接偶联成像剂，可用于肿瘤成像。
PC15681	SC 57461A	423169-68-0	LTA4水解酶的强效选择性抑制剂，A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM.
PC15761	TNP-470	129298-91-5	甲硫氨酸氨基肽酶-2（MetAP2）抑制剂，TNP-470 是甲硫氨酸氨肽酶-2 抑制剂，也是一种血管生成抑制剂。
PL13319	Tosedostat	238750-77-1	Tosedostat (CHR-2797) 是一种具有口服活性氨基肽酶 (aminopeptidase) 抑制剂。CHR-2797 对多种肿瘤细胞系均具有抗增殖作用。