PGE synthase

PGE synthase (Prostaglandin E synthase), which converts cyclooxygenase (COX)-derived prostaglandin H₂ (PGH₂) to PGE₂, is known to comprise a group of at least three structurally and biologically distinct enzymes. There are membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES).

mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli and downregulated by anti-inflammatory glucocorticoids as in the case of COX-2. It is functionally coupled with COX-2 in marked preference to COX-1. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. This enzyme is rather constitutively expressed in various cells and tissues and is functionally coupled with both COX-1 and COX-2. cPGES is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate PGE₂ production.

PGE synthase 相关产品（13）

货号	产品名	Cas
PC54243	CAY10526	938069-71-7
PC11544	Flurbiprofen	5104-49-4
PL09525	Furprofen	66318-17-0
PL09526	HPGDS inhibitor 2	2101626-26-8
PC54747	Limaprost	74397-12-9
PL09524	Limaprost-d3	1263190-37-9
PC11556	Mesalamine.	89-57-6
PL07372	Oxidopamine hydrochloride	28094-15-7
PL09523	PF-4693627	1312815-93-2
PL06737	PGS-IN-1	102271-49-8
PL09522	Vipoglanstat	1360622-01-0
PL09466	Zaloglanstat	1513852-12-4
PL09521	Zomepirac sodium salt	64092-48-4