HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶）

HIFs (Hypoxia-inducible factors) are transcription factors that respond to changes in available oxygen in the cellular environment, to be specific, to decreases in oxygen, or hypoxia. The HIF signaling cascade mediates the effects of hypoxia, the state of low oxygen concentration, on the cell. Hypoxia often keeps cells from differentiating. However, hypoxia promotes the formation of blood vessels, and is important for the formation of a vascular system in embryos, and cancer tumors. The hypoxia in wounds also promotes the migration of keratinocytes and the restoration of the epithelium. In general, HIFs are vital to development. In mammals, deletion of the HIF-1 genes results in perinatal death. HIF-1 has been shown to be vital to chondrocyte survival, allowing the cells to adapt to low-oxygen conditions within the growth plates of bones. HIF plays a central role in the regulation of human metabolism. Recently, several drugs that act as selective HIF prolyl-hydroxylase inhibitors have been developed.

HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶）相关产品（5）

货号	产品名	Cas	产品描述
PC10075	DMOG	89464-63-1	DMOG (Dimethyloxallyl Glycine) 是可渗透细胞，竞争型的 HIF-1α脯氨酰羟化酶 (HIF-PH) 抑制剂
PC10076	KC7F2	927822-86-4	KC7F2是一种有效的HIF-1途径抑制剂，可用作癌症治疗剂。KC7F2是HIF-1α的一个新型抑制剂，IC50值20 μM[1]。
PC10077	ML 228	1357171-62-0	ML228(CID-46742353)是HIF信号通路活化剂，可活化HIF以及下游EGFR。HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% in
PC10078	PX 12	141400-58-0	PX-12(IV-2)是可逆的硫氧还蛋白-1（Trx-1）抑制剂; 抑制MCF-7 和HT-29 cells细胞生长的IC50值分别为1.9和2.9 μM。
PC10074	毛壳菌素	1403-36-7	毛壳菌素是HIF-1的抑制剂，通过削弱HIF-1的转录，在低纳摩尔浓度下破坏HIF-1α和HIF-2α与p300的结合

HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶）

HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶） 相关产品（5）

HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶）相关产品（5）