HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶）

HIFs (Hypoxia-inducible factors) are transcription factors that respond to changes in available oxygen in the cellular environment, to be specific, to decreases in oxygen, or hypoxia. The HIF signaling cascade mediates the effects of hypoxia, the state of low oxygen concentration, on the cell. Hypoxia often keeps cells from differentiating. However, hypoxia promotes the formation of blood vessels, and is important for the formation of a vascular system in embryos, and cancer tumors. The hypoxia in wounds also promotes the migration of keratinocytes and the restoration of the epithelium. In general, HIFs are vital to development. In mammals, deletion of the HIF-1 genes results in perinatal death. HIF-1 has been shown to be vital to chondrocyte survival, allowing the cells to adapt to low-oxygen conditions within the growth plates of bones. HIF plays a central role in the regulation of human metabolism. Recently, several drugs that act as selective HIF prolyl-hydroxylase inhibitors have been developed.

HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶）相关产品（5）

货号	产品名	Cas
PC10075	DMOG	89464-63-1
PC10076	KC7F2	927822-86-4
PC10077	ML 228	1357171-62-0
PC10078	PX 12	141400-58-0
PC10074	毛壳菌素	1403-36-7

HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶）

HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶） 相关产品（5）

HIF/HIF Prolyl-Hydroxylase（HIF/HIF脯氨酰-羟化酶）相关产品（5）