Pyroptosis

Pyroptosis is a type of programmed cell death that features pore formation on the plasma membrane, cell swelling and plasma membrane disruption. Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation.

Gasdermin D (GSDMD), as the executive protein of pyroptosis, is activated and transferred to the membrane to induce glial rupture, resulting in the release of more inflammatory mediators.

Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of IL-1β/IL-18 and triggers pyroptosis. The proinflammatory effect of IL-1β/IL-18 and pyroptosis contributes to the development of autoimmune and inflammatory diseases.

Pyroptosis 相关产品（3）

货号	产品名	Cas	产品描述
PL10747	Ac-FEID-CMK TFA		Ac-FEID-CMK TFA 是一种有效的斑马鱼特异性 GSDMEb 衍生肽抑制剂。Ac-FEID-CMK TFA 可减轻感染性休克的死亡率和肾损伤。Ac-FEID-CMK TFA 在体内可抑制焦亡，减轻败血性 AKI (急性肾损伤)。Ac-FEID-CMK TFA 可抑制 caspy2 介导的非典型炎症小体通路。
PL10748	Disulfiram	97-77-8	Disulfiram (Tetraethylthiuram disulfide) 是特异性的乙醛脱氢酶 1 型 (ALDH1) 抑制剂，对酒精具有急性敏感性。Disulfiram 有效抑制人体和小鼠细胞中脂质体中的 GSDMD 孔形成，炎性体介导的细胞凋亡和 IL-1β 分泌。双硫仑 + Cu²⁺ 可增加细胞内 ROS 水平，引发卵巢癌干细胞凋亡。
PL10750	LDC7559	2407782-01-6	LDC7559 是一种消皮素 D (GSDMD) 的抑制剂，通过抑制中性粒细胞胞外杀菌网络 (NET) 后期阶段而发挥作用。