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Ceramidases are a group of enzymes that catalyze the hydrolysis of ceramide, dihydroceramide, and phytoceramide into sphingosine (SPH), dihydrosphingosine (DHS), and phytosphingosine (PHS), respectively, along with a free fatty acid. Ceramide catabolism is controlled by ceramidases that are pivotal in the pathophysiology of these diseases of altered lipid homeostasis such as Alzheimer’s disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular diseases. Ceramidases are classified into the acid, neutral, and alkaline ceramidase subtypes according to the pH optima for their catalytic activity.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PC15325 | ARN14974 | 1644158-57-5 | |
| PC15087 | Ceranib 1 | 328076-61-5 | |
| PC15330 | Ceranib-2 | 1402830-75-4 | |
| PC15376 | D-NMAPPD | 35922-06-6 |
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