Ceramidases

Ceramidases are a group of enzymes that catalyze the hydrolysis of ceramide, dihydroceramide, and phytoceramide into sphingosine (SPH), dihydrosphingosine (DHS), and phytosphingosine (PHS), respectively, along with a free fatty acid. Ceramide catabolism is controlled by ceramidases that are pivotal in the pathophysiology of these diseases of altered lipid homeostasis such as Alzheimer’s disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular diseases. Ceramidases are classified into the acid, neutral, and alkaline ceramidase subtypes according to the pH optima for their catalytic activity.

Ceramidases 相关产品（4）

货号	产品名	Cas	产品描述
PC15325	ARN14974	1644158-57-5	酸性神经酰胺酶抑制剂，ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase (IC50 = 79 nM).
PC15087	Ceranib 1	328076-61-5	神经酰胺酶抑制剂，Ceranib1 是一种神经酰胺酶 (ceramidase) 抑制剂。Ceranib1 能抑制细胞神经酰胺酶对外源性神经酰胺类似物的活性，诱导多种神经酰胺物质的积累，降低鞘氨醇和 S1P 水平。Ceranib1 能抑制细胞卵巢癌细胞增殖。
PC15330	Ceranib-2	1402830-75-4	细胞神经酰胺酶活性抑制剂，Ceranib-2 是一种有效的非脂质神经酰胺酶 (ceramidase) 抑制剂，可在 SKOV3 细胞中抑制细胞神经酰胺酶活性，IC50 为 28 μM。Ceranib-2 可诱导多种神经酰胺物质的积累，降低鞘氨醇和鞘氨醇1-磷酸 (S1P) 的水平，并诱导细胞凋亡 (apoptosis)。抗癌活性。
PC15376	D-NMAPPD	35922-06-6	神经酰胺酶抑制剂，诱导细胞凋亡，NMT1 inhibitor B13 (LCL4) is a myristoylCoA analog that acts as a small molecule inhibitor of NMT1 with IC50 of 77.6 uM, blocks Src myristoylation and Src localization to the cytoplasmic membrane.