Renin

Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin 相关产品（5）

货号	产品名	Cas	产品描述
PC14754	Aliskiren	173334-57-1	直接肾素抑制剂，Aliskiren(CGP 60536)是肾素抑制剂，IC50为1.5 nM。
PC14959	Aliskiren Hemifumarate	173334-58-2	肾素抑制剂，Aliskiren(CGP 60536)半富马酸盐是肾素的直接抑制剂，IC50为1.5 nM。
PL10953	SPH3127	1399849-02-5	SPH3127 (DRI 18) 是一种新型的、高度有效的、且具有口服活性的 direct renin 抑制剂 (recombinant human-renin IC50=0.4 nM，human plasma renin activity IC50=0.45 nM)。SPH3127 具有抗高血压作用，可用于高血压的研究。
PL10955	VTP-27999 Hydrochloride	1264191-73-2	VTP-27999盐酸盐是烷基胺Renin抑制剂，可作用于高血压。
PL10954	VTP-27999 TFA	1013937-63-7	VTP-27999 TFA 是烷基胺肾素抑制剂。