产品目录

Neprilysin

Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Neprilysin 相关产品(3)
货号 产品名 Cas 产品描述
PL07707 Racecadotril-d5 1246815-11-1 Racecadotril-d5 是 Racecadotril 的氘代物。Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的 NEP 活性,Ki 分别为 4500 和 6.1 nM。具有止泻效果。
PL07709 Sacubitril/Valsartan 936623-90-4 Sacubitril/Valsartan (LCZ696) 是由 Valsartan (an ARB) 和 Sacubitril (AHU377) 组成,摩尔比为 1:1,是一种首创的,口服有效的血管紧张素受体-脑啡肽酶 (ARN) 双抑制剂,用于研究高血压和心力衰竭。Sacubitril/Valsartan 可通过抑制炎症、氧化应激和细胞凋亡来改善糖尿性心肌病。
PL07708 TD-0212 TFA 1073549-11-7 TD-0212 TFA 是一种具有口服活性的、血管紧张素 II 型 1 受体 AT 1 和脑啡肽酶 (NEP) 的双抑制剂,其对 AT1 的 pKi 值为 8.9, 对 NEP 的 pIC50值为 9.2。