Glucosylceramide Synthase

Glucosylceramide synthase (GCS), converting ceramide to glucosylceramide, catalyzes the first reaction of ceramide glycosylation in sphingolipid metabolism. This glycosylation by GCS is a critical step regulating the modulation of cellular activities by controlling ceramide and glycosphingolipids (GSLs). An increase of ceramide in response to stresses, such as chemotherapy, drives cells to proliferation arrest and apoptosis or autophagy; however, ceramide glycosylation promptly eliminates ceramide and consequently, these induced processes, thus protecting cancer cells. Furthermore, persistently enhanced ceramide glycosylation can increase GSLs, participating in selecting cancer cells to drug resistance. GCS is overexpressed in diverse drug-resistant cancer cells and in tumors of breast, colon, and leukemia that display poor response to chemotherapy. As ceramide glycosylation by GCS is a rate-limiting step in GSL synthesis, inhibition of GCS sensitizes cancer cells to anticancer drugs and eradicates cancer stem cells.

Glucosylceramide Synthase 相关产品（7）

货号	产品名	Cas	产品描述
PL04020	Glucosylceramide synthase-IN-1	2601393-20-6	Glucosylceramide synthase-IN-1 (T-036) 是一种有效的、可穿过血脑屏障的和具有口服活性的 glucosylceramide synthase (GCS) 抑制剂，对人 GCS 和小鼠 GCS 的 IC50 分别为 31 nM 和 51 nM。Glucosylceramide synthase-IN-1 可用于戈谢病研究。
PL04021	Glucosylceramide synthase-IN-2	2597958-02-4	Glucosylceramide synthase-IN-2 (compound T-690) 是一种有效的、可透过血脑屏障的和具有口服活性的 glucosylceramide synthase (GCS) 抑制剂，对人 GCS 和小鼠 GCS 的 IC50 分别为 15 nM 和 190 nM。Glucosylceramide synthase-IN-2 非竞争性抑制 C8 神经酰胺和 UDP 葡萄糖。Glucosylceramide synthase-IN-2 可用于戈谢病研究。
PL04658	Ibiglustat	1401090-53-6	Ibiglustat (Venglustat) 是一种具有口服活性的，可透过血脑屏障的葡萄糖神经酰胺合成酶 (GCS) 抑制剂。Ibiglustat 可用于研究戈谢病 3 型、与 GBA 突变相关的帕金森病、法布瑞氏症、GM2 神经节苷脂病和常染色体显性多囊肾病。
PL04659	Ibiglustat (L-Malic acid)	1629063-78-0	Ibiglustat (Venglustat) L-Malic acid 是一种具有口服活性的，可透过血脑屏障的葡萄糖神经酰胺合成酶 (GCS) 抑制剂。Ibiglustat (Venglustat) L-Malic acid 可用于研究戈谢病 3 型、与 GBA 突变相关的帕金森病、法布瑞氏症、GM2 神经节苷脂病和常染色体显性多囊肾病。
PL04660	Ibiglustat succinate	1629063-80-4	Ibiglustat (Venglustat) succinate 是一种具有口服活性的，可透过血脑屏障地葡糖神经酰胺合酶 (GCS) 抑制剂。Ibiglustat succinate 可用于研究戈谢病 3 型、与 GBA 突变相关的帕金森病、法布瑞氏症、GM2 神经节苷脂病和常染色体显性多囊肾病。
PL01856	Miglustat-d9 (hydrochloride)	1883545-57-0	Miglustat-d9 (hydrochloride) 是 Miglustat (hydrochloride) 的氘代物。Miglustat hydrochloride 是一种葡萄糖神经酰胺合成酶抑制剂，可作用于 I 型戈谢病。
PL03047	Sinbaglustat	441061-33-2	Sinbaglustat (OGT2378) 是葡萄糖神经酰胺合成酶 (GCS) 和非溶酶体葡萄糖神经酰胺酶 (GBA2) 的双重抑制剂。Sinbaglustat 是一种可透过血脑屏障的的口服N-烷基亚氨基糖。Sinbaglustat 可用于与溶酶体功能障碍相关的中枢神经退行性疾病的研究。